My SimplyO3 Review: Years of Home Ozone Therapy From an HTMA Practitioner

By Matthew Coffman, HTMA practitioner and host of the Integrative Thoughts Podcast

Disclosure: I'm a SimplyO3 affiliate. If you buy through my links or use code ITP10, you get 10% off and I earn a small commission. I bought my own machine with my own money years before I ever became an affiliate, and I'm writing this because I still use it.

I get asked about ozone therapy a lot. Clients see it on podcasts, they hear about it from friends, and they want to know if a home ozone therapy machine is worth the money. So here's my honest take after owning a SimplyO3 since 2020, including what I use it for, what I'd do differently, and how I think about ozone alongside mineral balancing.

Short version

• I own the SimplyO3 Stratus 3.0 Complete Kit and I still use it.

• Setup was easy. The only confusing part was figuring out the oxygen tank.

• Customer service has been great. I broke a part early on and they replaced it.

• The biggest lesson: go low and slow. Most people are more toxic than they think.

• Code ITP10 gets you 10% off.

Why I bought a home ozone therapy machine

I first heard about ozone on podcasts, probably Dave Asprey and Ben Greenfield. Dave talked about it a lot in the context of mold.

Then I got diagnosed with Lyme. Part of my care was a series of ozone IVs at an integrative clinic, and I felt pretty good after them. As that part wrapped up, I was sick of the drive and the cost. It was a 30-minute drive each way, an hour in the chair, and somewhere around $150 to $200 a visit as best I remember. I wanted something I could use at home, as often as I wanted, and own for good.

To be clear, a home machine isn't an IV. They're different methods. But for me the math was simple. The cost of a handful of clinic visits got me a machine I could use daily for years.

Why I picked SimplyO3

Honestly, I didn't shop around much. I'd heard Micah from SimplyO3 on several podcasts, and SimplyO3 seemed to be the go-to home brand. The website looked professional, it had a ton of information on it, and I liked Micah's vibe. I'm still happy with the choice.

If you're comparing brands, here's what I'd look at:

• Warranty: SimplyO3 gives a lifetime warranty on the Stratus generator and its oxygen regulator for as long as you own it. Check whether the brand you're looking at covers both.

• Education: you'll have questions. A company with real guides and phone support matters more than a few extra features.

• A complete kit: buying the generator, regulator, bags, catheters and tubing piecemeal gets confusing fast. A kit takes the guesswork out.

• Ozone-resistant materials: ozone breaks down the wrong plastics and rubbers. Make sure the tubing and parts are built for it.

What's in the kit

The Stratus 3.0 Complete Kit ($1,999.99 at the time of writing) comes with the Stratus 3.0 generator, a pre-calibrated oxygen regulator (you pick the fitting), a water bubbler with a destruct, an ear insufflation set, two 3-chambered ozone bags, two 60 cc syringes, a 10-pack of catheters, ozone-resistant tubing, and quick-start instructions with links to video tutorials.

If you don't need the bubbler or the ear set, the Home-User Kit ($1,799.99) is the starter version. I'd still go Complete. The ear set is what I use most now.

Setup: easy, except the oxygen question

Setup was really easy. Putting the regulator on the tank was straightforward.

The one thing that confused me was oxygen. I didn't know if I needed a prescription oxygen tank or if I could get one from a welding or industrial gas supplier. I went out of my way to get the prescription kind, and later learned most home users just go with an industrial tank. That was the early days. SimplyO3 now has a clear write-up on 870 oxygen vs. 540 industrial oxygen, so read that before you order and pick the matching regulator. You'll save yourself the runaround I had.

How I use it: rectal insufflation, ear insufflation and more

I've tried just about every method the kit supports: rectal insufflation, ear insufflation, ozonated water and more.

Early on, while I was still dealing with a lot of Lyme, I mostly did rectal ozone insufflation. That was the method I leaned on the most during my detox from Lyme and heavy metals, and I noticed better energy during that stretch.

Now that I'm much healthier, I mostly do ear ozone insufflation with the ear set, with a rectal bag here and there. If I'm feeling sluggish or run down, a session is one of the first things I reach for.

As a backup for the family. Even if you don't use it every day, it's a great thing to have in the house. When I feel something coming on, I use it more.

My story with mercury and detox

I've done a lot of different detox work alongside HTMA and mineral balancing, so I can't credit any one thing. But ozone has been one of the most supportive pieces for me.

Part of my toxic load came from having seven mercury fillings removed the wrong way. I believe some of that mercury ended up affecting my brain, and it showed up as brain fog. During the stretch where I was detoxing hard, ozone sessions were part of my routine, and they seemed to help clear that fog. That's my experience, not a promise. Everybody's body is different.

How ozone fits with HTMA and mineral balancing

This is where I think most people get it wrong.

A lot of my clients are very toxic or dealing with chronic infections. Those people do best with a lower amount, used less often, with less volume in the bag, and they need someone to hold their hand. Some of them come to me after a bad experience, usually from jumping straight into something aggressive or using way too much at once. When you're very toxic, you can feel worse before you feel better as things start moving.

As people rebalance their minerals and their toxic load comes down, ozone tends to feel better and better for them. Pretty much everyone I know who uses ozone regularly and sticks with mineral balancing feels really good, including their energy and exercise performance. So be careful at the start, and it gets better the longer you go.

Not everyone can afford a machine. For those clients I sometimes point to ozone oil capsules or ozonated oil suppositories as a lower-cost way in.

My advice if you're just starting: go low and slow

Most people are more toxic than they think. Even the high-level biohackers I work with almost all have heavy metals, and that usually comes with other hidden stuff too.

• Start gentle. Ear insufflation at a low setting for short sessions, or a very small bag, for the first couple of weeks. See what your body tolerates.

• Ignore the podcast doses. You don't need the big numbers you hear about. Low amounts often work really well.

• More isn't better. When I was sick I went big, trying to hit everything hard, and some of those sessions wiped me out. When I backed off to lower amounts, less often, I saw a lot more improvement.

• Follow the instructions that come with the kit and SimplyO3's videos, and talk with a qualified practitioner before you start, especially if you're very toxic or have a health condition.

Downsides

Honestly, not many.

• Price. It's an investment. But compared with driving to the clinic and paying per visit, the math worked out for me.

• The oxygen tank. It's an extra step and an extra purchase, and it was the most confusing part for me. Since I originally bought mine, SimplyO3 added a concierge service that finds the oxygen tank suppliers near you for you, so that problem is mostly solved now.

• A learning curve. I was intimidated before I got it. Then it showed up and I realized how easy it was. It takes about an hour to figure it all out, and they walk you through everything. Just make sure to never breathe ozone directly, and use the destructs the kit comes with.

Medical ozone generator vs. cheap ozone generators: what to look for

People search for a "medical ozone generator" because they want one that's safe to use on the body. A lot of cheap no-name ozone generators online are built for deodorizing rooms, not for this. Here's what separates a real home ozone therapy machine from a cheap one:

• Oxygen-fed, not air-fed. Generators that make ozone from room air also make nitrogen byproducts. For ozone therapy you want a machine fed with pure oxygen from a tank.

• Ozone-resistant materials. Ozone eats through cheap plastics and rubber. The Stratus is built with quartz glass, titanium and silicone inside.

• A known concentration. You need to know how much ozone you're making. The Stratus comes with a concentration chart fitted to the machine (about 5 to 75 µg/mL across 11 settings). Most cheap units don't tell you anything.

• A matched oxygen regulator. The flow from the tank changes the concentration. SimplyO3 calibrates the regulator to the generator and swaps it for free if you picked the wrong fitting.

• Warranty and support. If a cheap unit dies in six months, you're on your own. SimplyO3 gives a lifetime warranty on the generator and regulator, plus phone support.

To be clear, SimplyO3 sells the Stratus as a home ozone generator, not a medical device. But it checks every box on that list, and the cheap ones usually check none.

Support and warranty

Customer service has been great. I broke the bubbler early on and they sent me a new one. The generator and regulator have a lifetime warranty, and there's phone support for as long as you own the equipment.

I'd already done a ton of research before buying because I was so sick, so I haven't gone through all of SimplyO3's education. What I have read is really good. If you're new, start there.

Is it worth it?

For me, yes. It's one of the best things I have in my toolkit, and even if you don't use it often, it's a great backup to have in the house. Start low, go slow, and pair it with the foundational work: minerals, diet, and getting your toxic load down.

If you want one, the Stratus 3.0 Complete Kit is what I'd get. Use code ITP10 for 10% off.

And if you want to know what's going on with your minerals before you start, that's what I do. Get an HTMA test.

FAQ

What's the best home ozone therapy machine?

For most people I'd say the SimplyO3 Stratus 3.0 Complete Kit. It's oxygen-fed, built from ozone-resistant materials, comes with everything you need for rectal and ear insufflation, and has a lifetime warranty.

Is the Stratus a medical ozone generator?

SimplyO3 sells it as a home ozone generator. It has what people are really after when they search for a medical ozone generator: oxygen feed, ozone-resistant materials, a known concentration, and real support.

Can you do rectal ozone insufflation at home?

Yes. That's what I did most when I first got my machine. The Stratus kits come with the bags and catheters for it. Start low and slow, follow the kit instructions, and work with a qualified practitioner.

Is SimplyO3 a good brand?

In my experience, yes. I've used mine for years, the support has been great, and the generator and regulator carry a lifetime warranty.

Which SimplyO3 kit should I buy?

I'd get the Stratus 3.0 Complete Kit. It adds the ear insufflation set and water bubbler over the Home-User Kit, and the ear set is what I use most.

Do I need a prescription oxygen tank?

Most home users use a 540 industrial oxygen tank. SimplyO3 explains both options in its 870 vs. 540 oxygen guide. Pick the regulator that matches your tank.

Is there a SimplyO3 discount code?

Yes. Code ITP10 takes 10% off.

How should a beginner start?

Low and slow. Start gentle, see how you feel, and build up only if your body handles it well. Follow the kit instructions and work with a qualified practitioner.